The 37-year-old was ultimately forced to stay put and has made plenty of unwanted headlines after finding himself stuck on the bench, refusing to enter the field as a substitute and struggling for end product in a season that has only delivered three goals through 16 appearances. WHAT HAPPENED? The five-time Ballon d’Or winner had been hoping to elsewhere for the 2022-23 campaign, as he pushed to leave during the summer transfer window. Making more negative headlines than positive.Portuguese wanted to leave over the summer.Our study seems to indicate that tiotropium, but not formoterol, is able to reduce energy expenditure in COPD patients, although both drugs elicit significant bronchodilation and are able to increase the distance walked in 6min. We did not find any significant correlation between the changes in lung function and those of parameters recorded with SenseWear Armband. Active energy expenditure at physical activity level of more than 3 METs decreased significantly after tiotropium at each 6-MWT, but not after formoterol. Total energy expenditure for each 6-MWT was not changed by formoterol, but decreased in significant manner 6h after the inhalation of tiotropium. There was a trend to an increase in calories and metabolic equivalents of task (METs) after formoterol and a decrease after tiotropium, but changes were not statistically significant. Formoterol significantly increased distance walked in 6min at 2h and at 4h, whereas tiotropium significantly increased it at all time points. Both formoterol and tiotropium induced a significantly sustained bronchodilation and influenced hyperinflation. At each time also spirometry was performed. Physical activity during each 6-MWT was assessed by the SenseWear Armband. 28 Consecutive COPD patients performed four 6-minute walking tests (6-MWTs) in 2 different days before and 2, 4 and 6h after the inhalation of formoterol 12microg or tiotropium 18microg, respectively.
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